產(chǎn)品詳情
簡單介紹：
Anti-CDT2抗體產(chǎn)品質(zhì)量穩(wěn)定，實驗效果明顯，貨期快，價格優(yōu)惠，歡迎垂詢訂購！我公司長期供應**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關試劑、熒光標記抗體、單克隆抗體、多克隆抗體、各種標記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-CDT2抗體用于**組化實驗,WB實驗,相應的標記抗體有HRP標記抗體,FITC標記,BIO等。
詳情介紹：
Rabbit Anti-CDT2
Cat. Number:
Anti-CDT2抗體KL-7935R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle Anti-CDT2抗體control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Tissue specificity: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.
Tissue specificity: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.
Also known as:
Lethal(2) denticleless protein Anti-CDT2抗體homolog; CDW1; CDW1; DCAF2; DDB1 and CUL4 associated factor 2; Ddb1- and Cul4-associated factor 2; Denticleless homolog; Denticleless homolog (Drosophila); Denticleless protein homolog; Dtl; DTL_HUMAN; L2DTL; Lethal(2) denticleless protein homolog; RA regulated nuclear matrix associated protein; RAMP; Retinoic acid regulated nuclear matrix associated protein; Retinoic acid-regulated nuclear matrix-associated protein.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Dog, Pig, Horse, Sheep, .
●
Immunogen: KLH conjugated synthetic peptide derived from human RAMP/CDT2.
●
Predicted Molecular Weight: 80kDa.
Storage:
Shipped at 4℃, Store at -20℃ Anti-CDT2抗體(Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions Anti-CDT2抗體must be determined by the end user.
Not yet tested in other applications.
Optimal working dilutions Anti-CDT2抗體must be determined by the end user.
kl821Ga01 C反應蛋白(CRP)多克隆抗體 Polyclonal Antibody to C Reactive Protein (CRP)
kl821Fi01 C反應蛋白(CRP)多克隆抗體 Polyclonal Antibody to C Reactive Protein (CRP)
kl089Ge01 脫氧膽酸(DC)多克隆抗體 Polyclonal Antibody to Deoxycholate (DC)
kl398Ge01 脫氫表雄酮(DHEA)多克隆抗體 Polyclonal Antibody to Dehydroepiandrosterone (DHEA)
kl560Po01 表皮生長因子(EGF)多克隆抗體 Polyclonal Antibody to Epidermal Growth Factor (EGF)
kl482Hu01 內(nèi)皮素1(EDN1)多克隆抗體 Polyclonal Antibody to Endothelin 1 (EDN1)
kl482Mu01 內(nèi)皮素1(EDN1)多克隆抗體 Polyclonal Antibody to Endothelin 1 (EDN1)
kl482Ra01 內(nèi)皮素1(EDN1)多克隆抗體 Polyclonal Antibody to Endothelin 1 (EDN1)
kl482Gu01 內(nèi)皮素1(EDN1)多克隆抗體 Polyclonal Antibody to Endothelin 1 (EDN1)
kl482Rb51 內(nèi)皮素1(EDN1)多克隆抗體 Polyclonal Antibody to Endothelin 1 (EDN1)
kl482Si01 內(nèi)皮素1(EDN1)多克隆抗體 Polyclonal Antibody to Endothelin 1 (EDN1)
kl482Ca01 內(nèi)皮素1(EDN1)多克隆抗體 Polyclonal Antibody to Endothelin 1 (EDN1)
kl482Po01 內(nèi)皮素1(EDN1)多克隆抗體 Polyclonal Antibody to Endothelin 1 (EDN1)
kl028Si01 紅細胞生成素(EPO)多克隆抗體 Polyclonal Antibody to Erythropoietin (EPO)
kl028Ca01 紅細胞生成素(EPO)多克隆抗體 Polyclonal Antibody to Erythropoietin (EPO)
kl028Po01 紅細胞生成素(EPO)多克隆抗體 Polyclonal Antibody to Erythropoietin (EPO)
kl028Cp01 紅細胞生成素(EPO)多克隆抗體 Polyclonal Antibody to Erythropoietin (EPO)
kl028Eq01 紅細胞生成素(EPO)多克隆抗體 Polyclonal Antibody to Erythropoietin (EPO)
kl116Hu01 紅細胞過氧化氫酶(EC)多克隆抗體 Polyclonal Antibody to Erythrocyte Catalase (EC)
kl116Po01 紅細胞過氧化氫酶(EC)多克隆抗體 Polyclonal Antibody to Erythrocyte Catalase (EC)
kl003Ge01 雌酮(E1)多克隆抗體 Polyclonal Antibody to Estrone (E1)
